Usb to Esata adaptor?

I have a Toshiba 4tb hd and was wondering if I can use a usb to esata adaptor? The drive is usb3 on the drive and a "regular" usb on the end going to the Tivo. So can I then use an adaptor to go to the Tivo? From what little I've read, it looks like only specified hard drives can be used with the Tivo? Can someone please explain all this to a noob such as myself in plain English? : )
Thank you in advance!

By the way, I have a series 4