TiVo Mini and power

Hello everyone,

I am experimenting with a Harmony 650 universal remote with my TiVo mini. Initially, when I would hit the "all off" button on the remote, it turned off the mini as well. I know the normal TiVo remote doesn't necessarily have a power button for the mini and it is normally left on, but that got me thinking....does it harm anything if the TiVo mini gets turned off and on? Would it miss something if it was off?

I eventually modified my Harmony's settings to keep it turned on all the time, but I was just curious!

Thanks everyone.